|
KMID : 0360220190600111037
|
|
Journal of the Korean Ophthalmological Society
2019 Volume.60 No. 11 p.1037 ~ p.1042
|
|
|
Dry Eye Syndrome and Morphological Changes of Meibomian Glands in Type 2 Diabetic Patients
|
|
Kwak Ji-Yoon
Choi Kyu-Ryong
Han Kyung-Eun
Jun Roo-Min
|
|
|
Abstract
|
|
|
Purpose: To evaluate the morphological changes of meibomian glands and dry eye syndrome in patients with type II diabetes.
Methods: The medical records of 72 diabetic patients referred to the ophthalmology clinic for the evaluation of diabetic retinopathy, who had dry eye symptoms, were retrospectively reviewed.
Results: A total of 72 patients, with an age of 56.3 ± 13.3 years, were analyzed. The group with diabetic retinopathy (52 patients) had a significantly lower tear film break-up time (p = 0.046), lower Schirmer’s test value (p = 0.005), and higher percentage of upper (p = 0.036) and lower (p = 0.017) meibomian gland area losses than the group without diabetic retinopathy (20 patients).
According to multilinear regression analyses considering sex, age, and diabetes-related characteristics, the Schirmer’s test value was significantly lower with increasing stage of diabetic retinopathy (β = -1.180, p = 0.016). The percentage of upper meibomian gland area loss was significantly increased with increasing age (β = 0.605, p < 0.001), glycosylated hemoglobin (β = 1.881, p = 0.011), and stage of diabetic retinopathy (β = 4.458, p = 0.001). The percentage of lower meibomian gland loss area was significantly increased with increasing age (β = 0.443, p = 0.001) and stage of diabetic retinopathy (β = 4.879, p = 0.001).
Conclusions: In patients with type 2 diabetes, the more severe the diabetic retinopathy, the more likely the meibomian gland loss will occur, so careful and appropriate treatment should be conducted.
|
|
|
KEYWORD
|
|
|
Diabetic retinopathy, Dry eye syndrome, Meibomian gland
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|
|